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KMID : 0545120060160091405
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Journal of Microbiology and Biotechnology
2006 Volume.16 No. 9 p.1405 ~ p.1409
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Breast Cancer Chemopreventive Activity of Polysaccharides from Starfish In Vitro
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Nam Kyung-Soo
Kim Cheorl-Ho
Shon Yun-Hee
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Abstract
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Polysaccharides from the starfish Asterina pectinifera were assessed in vitro for their chemopreventive potential in human breast cancer. The polysaccharides from A. pectinifera inhibited cell proliferation in the estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) human breast carcinoma cell lines. In addition, the polysaccharides were found to be an inhibitor of cytochrome P450 1A1-mediated ethoxyresorufin O-deethylase activity, and caused a dose-dependent inhibition of aromatase activity in microsomes isolated from a human placenta. There was a significant reduction in the ornithine decarboxylase activity to 30.7% of the control in the polysaccharide-treated MCF-7 breast cancer cells. Therefore, the polysaccharides from A. pectinifera merit further investigation with respect to breast cancer chemoprevention.
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KEYWORD
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Aromatase, Asterina pectinifera, breast cancer, cytochrome P450 1A1, ornithine decarboxylase
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